Description

Lersivirine (UK-453,061) is a potent and selective non-nucleoside reverse transcriptase inhibitor (NNRTI) developed for antiviral research. This high-purity compound is critical for pharmaceutical development and advanced biochemical studies targeting viral replication mechanisms. It is primarily utilized by research institutions, pharmaceutical R&D departments, and contract manufacturing organizations (CMOs) engaged in antiviral drug discovery and development programs.

Application

• Antiviral Drug Discovery: Serves as a key reference standard and active pharmaceutical ingredient (API) in the research and development of novel HIV-1 therapeutics.
• Biochemical Research: Used as a selective inhibitor in enzymatic assays to study the structure and function of HIV-1 reverse transcriptase and investigate mechanisms of drug resistance.
• Pharmacology & Toxicology Studies: Employed in in vitro and in vivo studies to evaluate pharmacokinetics, efficacy, and safety profiles of NNRTI-class compounds.
• Pharmaceutical Development: Acts as a critical intermediate or standard in the synthesis and analytical method development for next-generation antiviral medications.

Basic Information

Product Name	Lersivirine (UK-453,061)
CAS No.	473921-12-9
Molecular Formula	C₂₀H₂₁N₅O₂S
Molecular Weight	395.48 g/mol
Synonyms	UK-453,061; UK 453061; UK453061; 5-[(3,5-Diethyl-1H-pyrazol-1-yl)carbonyl]-2-[(methylsulfonyl)amino]-N-(2-pyridinyl)benzamide; 1H-Pyrazole-1-carboxamide, 5-[(3,5-diethyl-1H-pyrazol-1-yl)carbonyl]-N-(2-pyridinyl)-2-[(methylsulfonyl)amino]-
EINECS	Contact for details

Quality Control

Our Lersivirine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with cGMP guidelines for API manufacturing where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.