Description

(S)-o-Tolyl-Cbs-Oxazaborolidine, 0.5M I& CAS NO 463941-07-3 is a highly specialized, chiral oxazaborolidine catalyst, typically supplied as a 0.5M solution in an inert solvent. This compound is a critical reagent in asymmetric synthesis, enabling the production of enantiomerically pure intermediates with high selectivity and yield. It is essential for research and development laboratories and production facilities in the pharmaceutical and fine chemical industries focused on advanced chiral molecule synthesis.

Application

• Asymmetric Borane Reduction Catalyst: A key catalyst for the enantioselective reduction of prochiral ketones to chiral secondary alcohols, a fundamental transformation in pharmaceutical synthesis.
• Pharmaceutical Intermediate Synthesis: Used in the production of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity, such as certain antidepressants, antihypertensives, and antiviral agents.
• Fine Chemical Manufacturing: Enables the synthesis of complex, chiral building blocks for agrochemicals, flavors, and fragrances.
• Academic & Industrial R&D: A valuable tool for method development and exploring new asymmetric synthetic routes in organic chemistry.
• Process Chemistry Optimization: Employed to scale up and optimize chiral synthesis pathways for cost-effective and reproducible manufacturing.

Basic Information

Product Name	(S)-o-Tolyl-Cbs-Oxazaborolidine, 0.5M I& CAS NO 463941-07-3
CAS No.	463941-07-3
Molecular Formula	C18H20BNO
Molecular Weight	277.17 g/mol
Synonyms	(S)-2-Methyl-CBS-oxazaborolidine; (S)-o-Tolyl-CBS; (S)-2-Methyl-CBS Catalyst; (S)-3,3-Diphenyl-1-methyltetrahydro-3H-pyrrolo[1,2-c][1,3,2]oxazaborole; (S)-CBS Catalyst with o-Tolyl substituent; (S)-α,α-Diphenyl-2-pyrrolidinemethanol 1-Methyl-3,3-diphenyltetrahydro-1H-pyrrolo[1,2-c][1,3,2]oxazaborole; Corey-Bakshi-Shibata Catalyst (o-Tolyl variant); (S)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole
EINECS	Contact for details

Quality Control

Our (S)-o-Tolyl-Cbs-Oxazaborolidine solution is manufactured under strict quality control protocols to ensure batch-to-batch consistency and performance. Each lot is characterized by NMR, HPLC, and chiral analysis to verify chemical identity, assay concentration (0.5M), and enantiomeric purity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C. Due to its highly volatile solvent content and sensitivity to oxidation, the container must be kept tightly sealed and away from heat and ignition sources. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Assay (by 11B NMR or Titration)	0.45 M - 0.55 M
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Solvent Identity (GC)	Toluene or Tetrahydrofuran (as specified)
Water Content (Karl Fischer)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.