Description

Aplaviroc CAS NO 461443-59-4 is a potent and selective small-molecule antagonist of the CCR5 chemokine receptor. This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action. It is primarily utilized by researchers and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development (R&D): As a key reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies for antiviral therapies.
• Antiviral Drug Discovery: Investigation as a potential therapeutic agent for HIV-1 infection by blocking viral entry into host cells.
• Biochemical Assay Development: Used as a critical reagent in high-throughput screening (HTS) and binding assays to study CCR5 receptor interactions.
• Mechanism of Action Studies: Fundamental research tool for understanding the role of CCR5 in immunology, inflammation, and viral pathogenesis.
• Process Chemistry & Scale-up: Serves as a benchmark compound for developing and optimizing synthetic routes for CCR5 antagonists.

Basic Information

Product Name	Aplaviroc
CAS No.	461443-59-4
Molecular Formula	C₂₉H₄₁FN₄O₃
Molecular Weight	512.66 g/mol
Synonyms	GW-873140; ONO-4128; GW873140; 4,4-Difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]cyclohexanecarboxamide; (1S,3-exo)-3-[3-[3-Methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl 4,4-difluorocyclohexanecarboxylate
EINECS	Contact for details

Quality Control

Our Aplaviroc is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.