Description

Pexacerfont CAS NO 459856-18-9 is a selective, non-peptide antagonist of the corticotropin-releasing factor type 1 (CRF1) receptor. This compound is a critical research tool for investigating the role of the CRF system in stress-related disorders, including anxiety and depression. It is primarily utilized by pharmaceutical researchers, academic institutions, and R&D laboratories engaged in neuroscience and neuropharmacology studies.

Application

• Neuroscience Research: A key pharmacological tool for studying the hypothalamic-pituitary-adrenal (HPA) axis and stress response pathways.
• Drug Discovery: Used in preclinical studies to validate the CRF1 receptor as a therapeutic target for psychiatric and neurological conditions.
• Behavioral Pharmacology: Employed in animal models to assess anxiolytic and antidepressant-like effects of CRF1 receptor blockade.
• Biochemical Assays: Serves as a reference standard in receptor binding and functional assays (e.g., cAMP inhibition) to characterize new chemical entities.
• Academic Research: Facilitates fundamental research into the neurobiology of stress, addiction, and mood disorders.

Basic Information

Product Name	Pexacerfont
CAS No.	459856-18-9
Molecular Formula	C₂₀H₂₃N₃O₃
Molecular Weight	353.42 g/mol
Synonyms	BMS-562086; N-Butyl-N-ethyl-2,5-dimethyl-4-(2,4,6-trimethylphenyl)-1H-pyrrole-3-carboxamide; 4-(2,4,6-Trimethylphenyl)-N-butyl-N-ethyl-2,5-dimethyl-1H-pyrrole-3-carboxamide; Pexacerfontum; UNII-6J8U5QHQ8P
EINECS	Contact for details

Quality Control

Our Pexacerfont is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for research chemicals, and specifications can be aligned with customer requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.