Description

1-(2-Fluorobenzoyl)Piperidine-4-Carboxylic Acid is a high-purity fluorinated piperidine derivative, a crucial advanced pharmaceutical intermediate (API) and building block in modern organic synthesis. Its molecular architecture, featuring both a fluorobenzoyl moiety and a carboxylic acid functional group, makes it a versatile synthon for constructing complex molecules with targeted biological activity. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its fluorinated aromatic and carboxylic acid handle.
• Chemical Synthesis: Acts as a precursor for amide coupling reactions, esterification, and further functionalization to create diverse chemical libraries.
• Bioconjugation & Probe Development: The carboxylic acid group enables conjugation to biomolecules, peptides, or fluorescent tags for biochemical research tools.
• Agrochemical Research: Potential intermediate in the development of novel crop protection agents and pesticides.
• Material Science: Can be incorporated into specialty polymers or ligands for catalysis research.

Basic Information

Product Name	1-(2-Fluorobenzoyl)Piperidine-4-Carboxylic Acid
CAS No.	445226-98-2
Molecular Formula	C13H14FNO3
Molecular Weight	251.26 g/mol
Synonyms	4-Piperidinecarboxylic acid, 1-(2-fluorobenzoyl)-; 1-(2-Fluorobenzoyl)-4-piperidinecarboxylic acid; 2-Fluorophenyl(4-carboxypiperidin-1-yl)methanone; 1-(2-Fluorobenzoyl)piperidine-4-carboxylic acid; 445226-98-2; 2-Fluorobenzoyl piperidine-4-carboxylic acid; 1-(o-Fluorobenzoyl)piperidine-4-carboxylic acid; 4-Carboxy-1-(2-fluorobenzoyl)piperidine
EINECS	Contact for details

Quality Control

Our 1-(2-Fluorobenzoyl)Piperidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.