Description

Methyl 4-(1,1-Difluoroethyl)Benzoate is a high-purity fluorinated aromatic ester building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the difluoroethyl group, enabling precise molecular modifications. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoroethyl group can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Polymer & Specialty Chemicals: Employed as a monomer or modifier in the creation of specialty polymers, coatings, and additives with tailored surface characteristics and chemical resistance.
• Cross-Coupling Reactions: Functions as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing complex biaryl systems.
• Fluorine Chemistry Research: An important reagent for academic and industrial research exploring new methodologies in fluorine chemistry and organofluorine compound synthesis.

Basic Information

Product Name	Methyl 4-(1,1-Difluoroethyl)Benzoate
CAS No.	444915-84-8
Molecular Formula	C10H10F2O2
Molecular Weight	200.18 g/mol
Synonyms	Methyl 4-(1,1-Difluoroethyl)benzoate; Benzoic acid, 4-(1,1-difluoroethyl)-, methyl ester; 4-(1,1-Difluoroethyl)benzoic acid methyl ester; Methyl p-(1,1-difluoroethyl)benzoate; 1-[4-(Methoxycarbonyl)phenyl]-1,1-difluoroethane
EINECS	Contact for details

Quality Control

Our production of Methyl 4-(1,1-Difluoroethyl)Benzoate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to reliable supply and traceability supports your R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Purity (HPLC/GC)	≥99.0% (High Purity Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.