Description

4-Chloro-5-Methyl-7-(2-C-Methyl-β-D-Ribofuranosyl)-7H-Pyrrolo[2,3-D]Pyrimidine is a high-purity nucleoside analog building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel antiviral and anticancer agents, particularly those targeting RNA-based mechanisms. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require reliable, high-quality raw materials for their discovery pipelines and scale-up activities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside-based antiviral drugs and oncology therapeutics.
• Antiviral Drug Development: Used in research targeting RNA viruses, where modified nucleosides are incorporated to inhibit viral replication.
• Oncology Research: Serves as a building block for developing novel chemotherapeutic agents that interfere with cancer cell DNA/RNA synthesis.
• Biochemical Research: Employed in enzymatic studies and as a substrate or inhibitor for nucleoside-processing enzymes.
• Process Chemistry & Scale-Up: Used in the development and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical manufacturing.

Basic Information

Product Name	4-Chloro-5-Methyl-7-(2-C-Methyl-β-D-Ribofuranosyl)-7H-Pyrrolo[2,3-D]Pyrimidine
CAS No.	443642-55-5
Molecular Formula	C13H16ClN3O4
Molecular Weight	313.74 g/mol
Synonyms	4-Chloro-5-methyl-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine; 2'-C-Methyl-4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine ribonucleoside; 4-Chloro-5-methyl-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine; 7-(2-C-Methyl-β-D-ribofuranosyl)-4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine; CAS 443642-55-5
EINECS	Contact for details

Quality Control

Every batch of our 4-Chloro-5-Methyl-7-(2-C-Methyl-β-D-Ribofuranosyl)-7H-Pyrrolo[2,3-D]Pyrimidine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and mass spectrometry, is supplied with each shipment to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.