Description

Bicyclo[2.2.1]Heptane-2-Acetonitrile, 2-Hydroxy-1,3,3-Trimethyl-, (1R,2S,4S)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its rigid bicyclic framework and functional group array make it a valuable precursor for constructing complex molecular architectures with precise three-dimensional control. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its specific stereochemistry is critical for biological activity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the development of novel, stereoselective pesticides and herbicides where the specific spatial orientation of the molecule influences efficacy and environmental profile.
• Asymmetric Catalysis Ligand Precursor: The hydroxyl and nitrile functionalities provide handles for modification into novel chiral ligands and organocatalysts.
• Material Science Research: Employed in academic and industrial R&D for creating specialty polymers or liquid crystals with unique structural properties derived from the norbornane skeleton.
• Flavor & Fragrance Chemistry: Potential use as an intermediate for synthesizing complex, camphor-like odorants and flavor molecules due to its terpenoid-related structure.

Basic Information

Item	Detail
Product Name	Bicyclo[2.2.1]Heptane-2-Acetonitrile, 2-Hydroxy-1,3,3-Trimethyl-, (1R,2S,4S)- (9Ci)
CAS No.	439689-16-4
Molecular Formula	C12H19NO
Molecular Weight	193.28 g/mol
Synonyms	(1R,2S,4S)-2-Hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptane-2-acetonitrile; (1R,2S,4S)-2-Hydroxy-1,3,3-trimethyl-2-norbornaneacetonitrile; (-)-Camphor Acetonitrile derivative; 2-(2-Hydroxy-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)acetonitrile; Chiral Norbornane Acetonitrile; (1R,2S,4S)-HMTBA
EINECS	Contact for details

Quality Control

Our Bicyclo[2.2.1]Heptane-2-Acetonitrile, 2-Hydroxy-1,3,3-Trimethyl-, (1R,2S,4S)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.