Description

Bupropion (R)-Isomer is the single enantiomer form of the widely used antidepressant and smoking cessation aid, bupropion. This high-purity chiral intermediate is critical for pharmaceutical research and development, enabling the study of stereospecific activity and the potential creation of novel enantiopure therapeutics. It is primarily utilized by pharmaceutical companies, advanced research institutions, and fine chemical manufacturers focused on neuropharmacology and chiral drug synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the research and development of enantiomerically pure central nervous system (CNS) drugs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Metabolic Studies: Employed in preclinical and clinical research to investigate the distinct pharmacokinetics, metabolism, and receptor binding profiles of the (R)-enantiomer.
• Chiral Catalyst/Resolution Studies: Acts as a model compound in developing and optimizing asymmetric synthesis routes or chiral separation techniques.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medicinal chemistry, neurochemistry, and pharmacology.
• Process Chemistry Development: Supports the scale-up and optimization of manufacturing processes for enantiopure active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Bupropion (R)-Isomer
CAS No.	437723-96-1
Molecular Formula	C13H18ClNO
Molecular Weight	239.74 g/mol
Synonyms	(2R)-2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one; (R)-Bupropion; (R)-2-(tert-Butylamino)-3'-chloropropiophenone; (R)-Amfebutamone; (R)-Wellbutrin; BW 323U (R-enantiomer); (R)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone
EINECS	Contact for details

Quality Control

Our Bupropion (R)-Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, identity confirmation by IR and NMR, and stringent purity assays. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all specifications and test results to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.5%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.