Description

3-(2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyridine is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone methodology for constructing complex molecules. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring complex aryl-aryl linkages.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the synthesis of sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis & Scale-Up: A vital starting material for contract research and manufacturing organizations (CROs/CMOs) performing custom synthesis from milligram to kilogram scale.

Basic Information

Product Name	3-(2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyridine
CAS No.	425378-79-6
Molecular Formula	C17H19BFNO2
Molecular Weight	299.15 g/mol
Synonyms	2-Fluoro-5-(pyridin-3-yl)phenylboronic acid pinacol ester; 3-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine; (2-Fluoro-5-(3-pyridyl)phenyl)boronic acid pinacol ester; 3-(5-Boronic acid pinacol ester-2-fluorophenyl)pyridine; 3-(2-Fluoro-5-(pinacolboranyl)phenyl)pyridine; 2-Fluoro-5-(3-pyridinyl)benzeneboronic acid, pinacol ester
EINECS	Contact for details

Quality Control

Our production of 3-(2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, and well-ventilated place. Due to its hygroscopic and easily oxidized nature, the container should be allowed to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.