Description

2-Fluoro-5-Nitrophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is essential for modern cross-coupling reactions, particularly Suzuki-Miyaura couplings, enabling the efficient construction of complex biaryl structures. It is a critical building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing fluorinated and nitrated aromatic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the unique properties of the fluorine and nitro substituents.
• Material Science Research: Serves as a monomer or building block for creating functional polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and diagnostic agents for biochemical research.
• Catalyst & Ligand Development: Used to create novel ligands for transition metal catalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs serving the global life sciences industry.

Basic Information

Item	Details
Product Name	2-Fluoro-5-Nitrophenylboronic Acid Pinacol Ester
CAS No.	425378-68-3
Molecular Formula	C₁₂H₁₅BFNO₄
Molecular Weight	267.06 g/mol
Synonyms	2-Fluoro-5-nitrophenylboronic acid pinacol ester; (2-Fluoro-5-nitrophenyl)boronic acid pinacol ester; 5-Nitro-2-fluorophenylboronic acid pinacol ester; 2-Fluoro-5-nitrobenzeneboronic acid pinacol ester; Pinacol (2-fluoro-5-nitrophenyl)boronate; 4,4,5,5-Tetramethyl-2-(2-fluoro-5-nitrophenyl)-1,3,2-dioxaborolane; CAS 425378-68-3
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Nitrophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.