Description

2-Keto-3-Methylbutyric Acid-13C5, 3-D1 Sodium Salt is a high-purity, isotopically labeled compound essential for advanced research and analytical applications. This stable isotope-labeled derivative of 2-keto-3-methylbutyric acid is a critical tool for metabolic pathway tracing, quantitative mass spectrometry, and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions specializing in metabolomics and stable isotope-resolved analysis.

Application

• Metabolomics & Biomarker Discovery: Used as an internal standard for the precise quantification of branched-chain amino acid (BCAA) metabolites in complex biological samples via LC-MS/MS and GC-MS.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as a tracer to study the catabolic pathways of BCAAs (valine, leucine, isoleucine) in preclinical and clinical research.
• Nutritional & Metabolic Research: Enables detailed investigation into disorders of BCAA metabolism, such as Maple Syrup Urine Disease (MSUD), and studies on energy metabolism.
• Synthesis of Labeled Compounds: Acts as a key, isotopically labeled building block for the synthesis of more complex labeled pharmaceuticals or biochemical probes.
• Quality Control & Method Validation: Employed in analytical laboratories to develop and validate highly accurate and sensitive assays for clinical diagnostics and bioanalytical testing.

Basic Information

Product Name	2-Keto-3-Methylbutyric Acid-13C5, 3-D1 Sodium Salt
CAS No.	420095-74-5
Molecular Formula	13C5H4DNaO3
Molecular Weight	Contact for details
Synonyms	2-Oxoisovaleric Acid-13C5,3-D1 Sodium Salt; 3-Methyl-2-oxobutyric Acid-13C5,3-D1 Sodium Salt; α-Ketoisovaleric Acid-13C5,3-D1 Sodium Salt; KIV-13C5,3-D1 Sodium Salt; Sodium 2-Keto-3-methylbutyrate-13C5,3-D1; Sodium α-Ketoisovalerate-13C5,3-D1; (13C5,3-D1)-2-Keto-3-methylbutyric Acid Sodium Salt
EINECS	Contact for details

Quality Control

Every batch of 2-Keto-3-Methylbutyric Acid-13C5, 3-D1 Sodium Salt is manufactured and analyzed under strict quality systems to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Our products undergo rigorous quality testing, including NMR, HPLC, and mass spectrometry, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.