Description

Casopitant is a potent and selective neurokinin-1 (NK1) receptor antagonist. This compound is of significant interest in pharmaceutical research and development for its potential therapeutic applications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of treatments for conditions such as chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).

Application

• Pharmaceutical Research & Development: As a key active pharmaceutical ingredient (API) or intermediate in the development of antiemetic drugs targeting the NK1 receptor pathway.
• Preclinical Studies: For in vitro and in vivo pharmacological evaluation of NK1 receptor antagonism and its effects on emesis and other central nervous system processes.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Chemical Synthesis: Used as a sophisticated building block or intermediate for the synthesis of more complex molecules or novel chemical entities in medicinal chemistry.
• Mechanistic Studies: Employed in biochemical and neurological research to study the role of substance P and the NK1 receptor in various physiological and pathological conditions.

Basic Information

Product Name	Casopitant
CAS No.	414910-27-3
Molecular Formula	C23H28FN3O2
Molecular Weight	397.49 g/mol
Synonyms	GW679769; GW-679769; (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholin-4-ylmethylmorpholine; 4-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]morpholine
EINECS	Contact for details

Quality Control

Our Casopitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.