Description

4'-Fluoro-2-Methyl-[1,1'-Biphenyl]-4-Carboxylic Acid is a high-purity biphenyl carboxylic acid derivative, distinguished by its fluorine and methyl substituents which impart unique electronic and steric properties. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in modern synthetic chemistry. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in non-steroidal anti-inflammatory drugs (NSAIDs) and other small molecule therapeutics.
• Agrochemical Synthesis: Used as a precursor in the manufacture of advanced herbicides, fungicides, and plant growth regulators, leveraging its biphenyl core.
• Liquid Crystal & OLED Materials: Serves as a building block for electronic materials due to its rigid, substituted biphenyl structure, which is essential for charge transport and molecular alignment.
• Organic Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Polymer Chemistry: Acts as a monomer or modifier for engineering plastics and high-performance polymers to enhance thermal and chemical resistance.
• Research & Development: A valuable tool for medicinal chemistry and chemical biology research in structure-activity relationship (SAR) studies.

Basic Information

Product Name	4'-Fluoro-2-Methyl-[1,1'-Biphenyl]-4-Carboxylic Acid
CAS No.	406234-42-2
Molecular Formula	C14H11FO2
Molecular Weight	230.24 g/mol
Synonyms	4'-Fluoro-2-methylbiphenyl-4-carboxylic acid; 2-Methyl-4'-fluorobiphenyl-4-carboxylic acid; [1,1'-Biphenyl]-4-carboxylic acid, 4'-fluoro-2-methyl-; 4-Fluoro-2'-methylbiphenyl-4'-carboxylic acid; 4-Carboxy-3-methyl-4'-fluorobiphenyl; 2-Methyl-4'-(fluoro)[1,1'-biphenyl]-4-carboxylic acid; Biphenyl-4-carboxylic acid, 4'-fluoro-2-methyl derivative
EINECS	Contact for details

Quality Control

Our 4'-Fluoro-2-Methyl-[1,1'-Biphenyl]-4-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing including HPLC, NMR, and GC-MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.