Description

3-Butyn-2-Ol, 4-(2-Pyridinyl)-, (2R)- (9Ci) is a chiral, non-racemic organic building block featuring both an alkyne and a pyridine moiety. This compound is of significant value in pharmaceutical and agrochemical research as a key intermediate for constructing complex molecules with specific stereochemistry. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological and inflammatory pathways.
• Agrochemical Research: Used in the development of novel, stereoselective pesticides and herbicides where the specific (2R) configuration can influence biological activity.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands used in asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Material Science: Employed in the synthesis of specialized polymers and advanced organic materials that require precise molecular architecture.
• Academic & Industrial R&D: A valuable tool for method development and exploring new chemical spaces in synthetic organic chemistry laboratories.

Basic Information

Product Name	3-Butyn-2-Ol, 4-(2-Pyridinyl)-, (2R)- (9Ci)
CAS No.	405065-75-0
Molecular Formula	C9H9NO
Molecular Weight	147.17 g/mol
Synonyms	(2R)-4-(Pyridin-2-yl)but-3-yn-2-ol; (R)-4-(2-Pyridinyl)-3-butyn-2-ol; (R)-4-(Pyridin-2-yl)but-3-yn-2-ol; 4-(2-Pyridinyl)-3-butyn-2-ol, (2R)-; (R)-Homoalkynyl Alcohol Pyridine Derivative; Chiral Pyridyl Alkyne Alcohol; 405065-75-0
EINECS	Contact for details

Quality Control

Our production of 3-Butyn-2-Ol, 4-(2-Pyridinyl)-, (2R)- (9Ci) adheres to stringent quality protocols suitable for research and development applications. Each batch undergoes comprehensive analytical characterization, including chiral purity analysis, to ensure identity, strength, and composition. A Certificate of Analysis (COA) detailing specifications such as chiral purity (enantiomeric excess), chemical purity (by HPLC/GC), and residual solvent levels is provided with every shipment to guarantee reliable and reproducible performance in your synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC / GC)	≥ 95.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.