Description

Fty720 (R)-Phosphate CAS NO 402616-23-3 is the biologically active phosphate ester of the (R)-enantiomer of Fingolimod, a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. This high-purity compound is a critical reference standard and active pharmaceutical ingredient (API) intermediate for advanced pharmaceutical research and development. It is essential for researchers and manufacturers in the fields of immunology and neurology, particularly for developing next-generation therapeutics targeting autoimmune diseases and multiple sclerosis.

Application

• Pharmaceutical Reference Standard: Serves as a primary analytical standard for quality control and method validation in API and finished drug product manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: A key synthetic precursor in the production of S1P receptor modulator drugs.
• Biochemical Research: Used in vitro and in vivo studies to investigate S1P receptor signaling pathways, lymphocyte trafficking, and immunomodulation.
• Drug Discovery & Development: Employed in preclinical and clinical research for novel therapies targeting autoimmune conditions, such as multiple sclerosis.
• Metabolite Studies: Critical for pharmacokinetic and pharmacodynamic research to understand the metabolism and activity of sphingosine-1-phosphate receptor agonists.

Basic Information

Product Name	Fty720 (R)-Phosphate
CAS No.	402616-23-3
Molecular Formula	C19H33NO6P
Molecular Weight	402.45 g/mol
Synonyms	(R)-Fingolimod Phosphate; (R)-FTY720 Phosphate; 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol Phosphate (R-enantiomer); (R)-2-Amino-2-[2-(4-n-octylphenyl)ethyl]propane-1,3-diol 1-(Dihydrogen Phosphate); S1P Receptor Agonist (R)-enantiomer Phosphate; (R)-Fingolimod 1-Phosphate; AXON 1388 (R)-Phosphate; GILENYA® (Fingolimod) Related Compound (R)-enantiomer Phosphate
EINECS	Contact for details

Quality Control

Our Fty720 (R)-Phosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical reference standards and API intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-enantiomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.