Description

Etriciguat is a high-purity pharmaceutical intermediate and research chemical with significant therapeutic potential. This compound is of primary interest for its role in the development of novel cardiovascular and pulmonary hypertension treatments. It is essential for pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions engaged in cardiopulmonary drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of soluble guanylate cyclase (sGC) stimulators for cardiovascular therapies.
• Research & Development: Used in preclinical and clinical research studies targeting pulmonary arterial hypertension (PAH) and chronic heart failure.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.
• Mechanistic Studies: Employed in biochemical assays to study the sGC signaling pathway and nitric oxide (NO) independent vasodilation.
• Formulation Development: Utilized in the development of dosage forms for next-generation cardiopulmonary medications.

Basic Information

Product Name	Etriciguat
CAS No.	402595-29-3
Molecular Formula	C20H21N5O4
Molecular Weight	395.41 g/mol
Synonyms	BAY 1021189; BAY-1021189; 4-({(4-Carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic Acid; 4-[[[4-Carboxybutyl][2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic Acid; BAY1021189
EINECS	Contact for details

Quality Control

Our Etriciguat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR, MS) to ensure it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.