Description

Methyl 3-(4-Fluorophenyl)Prop-2-Ynoate is a high-purity fluorinated alkyne ester building block, essential for advanced organic synthesis. Its core value lies in the strategic combination of a reactive terminal alkyne group and a fluorinated aromatic system, enabling precise molecular construction. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex molecules for drug discovery, particularly in developing kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used to build novel active ingredients for crop protection agents, leveraging the fluorine atom for enhanced metabolic stability and bioavailability.
• Click Chemistry: Serves as a critical component in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and materials science applications.
• Liquid Crystal & OLED Material Precursor: Employed in the development of advanced fluorinated organic electronic materials.
• Cross-Coupling Reactions: Acts as a versatile coupling partner in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions.
• Academic & Contract Research: A valuable reagent for methodological development and synthetic chemistry research in academic and CRO laboratories.

Basic Information

Product Name	Methyl 3-(4-Fluorophenyl)Prop-2-Ynoate
CAS No.	42122-44-1
Molecular Formula	C10H7FO2
Molecular Weight	178.16 g/mol
Synonyms	Methyl 4-Fluorophenylpropiolate; Methyl (4-Fluorophenyl)propiolate; 3-(4-Fluorophenyl)prop-2-ynoic acid methyl ester; 4-Fluorophenylpropiolic Acid Methyl Ester; Propiolic acid, 3-(4-fluorophenyl)-, methyl ester; Methyl 3-(p-Fluorophenyl)propiolate
EINECS	Contact for details

Quality Control

Our Methyl 3-(4-Fluorophenyl)Prop-2-Ynoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Typical 98-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.