Description

D-Proline, 1-Methyl-, Ethyl Ester (9Ci) is a non-natural, chiral proline derivative, a high-value building block in asymmetric synthesis. Its unique stereochemistry and functional group make it a critical intermediate for constructing complex molecules with precise three-dimensional control. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs), chiral catalysts, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic agents, including peptidomimetics and enzyme inhibitors.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce high enantioselectivity.
• Peptide Chemistry: Incorporation into custom peptide sequences to study structure-activity relationships or to confer metabolic stability.
• Agrochemical Research: Serves as a building block for developing chiral active ingredients with improved efficacy and environmental profile.
• Flavor & Fragrance Industry: Potential intermediate for the synthesis of complex, chiral aroma compounds.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	D-Proline, 1-Methyl-, Ethyl Ester (9Ci)
CAS No.	42002-99-3
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	Ethyl (2R)-1-methylpyrrolidine-2-carboxylate; D-1-Methylproline Ethyl Ester; (R)-1-Methylpyrrolidine-2-carboxylic Acid Ethyl Ester; Ethyl D-1-Methylprolinate; (R)-1-Methyl-2-pyrrolidinecarboxylic Acid Ethyl Ester; 42002-99-3; UNII-9F6L5K3F3F
EINECS	Contact for details

Quality Control

Our D-Proline, 1-Methyl-, Ethyl Ester (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.