Description

2',3'-Dideoxy-3'-Fluorouridine is a fluorinated nucleoside analog, a key building block in medicinal chemistry and antiviral research. This compound is valued for its role as a precursor in the synthesis of modified nucleotides and potential therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in the development of novel antiviral and anticancer compounds.

Application

• Antiviral Drug Research: Serves as a critical synthetic intermediate in the development of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Medicinal Chemistry: Used as a building block for creating novel nucleoside analogs to explore structure-activity relationships (SAR) and improve drug efficacy.
• Biochemical Research: Employed in studies investigating enzyme mechanisms, such as those of polymerases and kinases, due to its modified sugar moiety.
• Oncology Research: Investigated as a precursor for prodrugs or active metabolites in the development of targeted cancer therapies.
• Process Development & Scale-up: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for process optimization and kilogram-scale synthesis under cGMP conditions.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical manufacturing.

Basic Information

Product Name	2',3'-Dideoxy-3'-Fluorouridine
CAS No.	41107-56-6
Molecular Formula	C9H11FN2O5
Molecular Weight	246.20 g/mol
Synonyms	3'-Fluoro-2',3'-dideoxyuridine; 3'-F-ddU; 2',3'-Dideoxy-3'-fluorouridine; 1-[(2R,5S)-5-Fluoro-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 3'-Fluoro-2',3'-dideoxy-Uridine; FDDU; 3'-F-2',3'-ddU; 41107-56-6
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxy-3'-Fluorouridine is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.