Description

N(2),N(2),7-Trimethylguanosine is a modified nucleoside, specifically a trimethylated derivative of guanosine, which plays a significant role in RNA biology and epigenetic research. This compound is essential for studying RNA modification pathways, tRNA structure, and the intricate mechanisms of post-transcriptional gene regulation. It serves as a critical reference standard and biochemical tool for researchers and manufacturers in the fields of pharmaceutical development, molecular diagnostics, and life science research.

Application

• Biochemical Research: Used as a high-purity reference standard in the study of RNA modifications, epitranscriptomics, and tRNA function.
• Pharmaceutical Intermediates: Serves as a key building block or intermediate in the synthesis of novel nucleoside-based therapeutics and prodrugs.
• Diagnostic Reagent Manufacturing: Employed in the production of reagents and kits for molecular biology assays and diagnostic tests.
• Enzymology Studies: Acts as a substrate or inhibitor for methyltransferase and other RNA-modifying enzymes to elucidate their activity and mechanism.
• Academic Research: Fundamental tool in universities and research institutes for investigating gene expression regulation and RNA metabolism.

Basic Information

Product Name	N(2),N(2),7-Trimethylguanosine
CAS No.	40027-70-1
Molecular Formula	C13H19N5O5
Molecular Weight	325.32 g/mol
Synonyms	2,2,7-Trimethylguanosine; N2,N2,7-Trimethylguanosine; 7-Methyl-2-(methylamino)-6-oxo-1H-purin-9-yl-2-C-methyl-β-D-ribofuranoside; 2,2,7-Trimethylguanosine; 2,2,7-trimethylguanosine; N2,N2,7-trimethylguanosine; Guanosine, N2,N2,7-trimethyl-; 2-(Dimethylamino)-7-methyl-6-oxo-1H-purin-9-yl-2-C-methyl-β-D-ribofuranoside
EINECS	Contact for details

Quality Control

Our N(2),N(2),7-Trimethylguanosine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and rigorous tests for residual solvents and moisture. We provide full traceability and Certificates of Analysis (COA) are available upon request to ensure compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.