Description

4-(Difluoro-Methanesulfonyl)-Benzoic Acid is a high-value, multi-functional aromatic building block characterized by its unique combination of a benzoic acid core with a difluoromethanesulfonyl substituent. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its specific fluorine and sulfone chemistry enables precise molecular tuning. It is primarily needed by research chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with targeted properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and anti-inflammatory research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the fluorine atoms for enhanced bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of monomers for high-performance polymers, such as polyimides or sulfonated materials.
• Fluorinated Building Block: Provides a source of difluoromethanesulfonyl and carboxylic acid functional groups for parallel and combinatorial chemistry libraries.
• Chemical Biology Probes: Utilized in the design of activity-based probes and molecular tags for studying biological systems.

Basic Information

Product Name	4-(Difluoro-Methanesulfonyl)-Benzoic Acid
CAS No.	4837-22-3
Molecular Formula	C8H6F2O4S
Molecular Weight	236.19 g/mol
Synonyms	4-(Difluoromethanesulfonyl)benzoic acid; Benzoic acid, 4-[(difluoromethyl)sulfonyl]-; 4-[(Difluoromethyl)sulfonyl]benzoic acid; α,α-Difluoro-4-(carboxyphenyl)methyl sulfone; 4-Carboxy-α,α-difluorobenzenemethanesulfonic acid S,S-dioxide; 4-(Difluoromethylsulfonyl)benzoic acid
EINECS	Contact for details

Quality Control

Our 4-(Difluoro-Methanesulfonyl)-Benzoic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where required, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.