Description

4-(Difluoromethoxy)Benzoic Acid is a high-purity fluorinated aromatic building block of significant commercial interest. This compound is valued for its role in introducing the difluoromethoxy moiety, a key structural feature known to enhance metabolic stability and lipophilicity in advanced molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a key raw material in the production of fluorinated liquid crystals for high-performance displays (LCDs).
• Organic Synthesis & Chemical Research: Employed as a versatile reagent in academic and industrial laboratories for introducing fluorine-containing functional groups into complex organic frameworks.
• Polymer Modification: Acts as a monomer or modifier in the synthesis of specialty polymers to impart unique chemical resistance or surface properties.

Basic Information

Product Name	4-(Difluoromethoxy)Benzoic Acid
CAS No.	4837-20-1
Molecular Formula	C8H6F2O3
Molecular Weight	188.13 g/mol
Synonyms	Benzoic acid, 4-(difluoromethoxy)-; p-(Difluoromethoxy)benzoic acid; 4-(Difluoromethoxy)benzoic acid; Difluoromethoxybenzoic acid; α,α-Difluoro-p-methoxybenzoic acid; 4837-20-1 (CAS); DFMBA
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.