Description

(E)-Doxepin Hydrochloride CAS NO 4698-39-9 is the pure geometric isomer of the tricyclic antidepressant compound doxepin. This high-purity isomer is critical for advanced pharmaceutical research and development, particularly in studies focusing on receptor selectivity and metabolic pathways. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in neuropharmacology, drug discovery, and the development of novel therapeutic agents.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral building block in the synthesis of advanced pharmaceutical formulations.
• Pharmacological Research: Used in in-vitro and in-vivo studies to investigate the specific biological activity and binding affinity of the (E)-isomer.
• Reference Standard: Employed as a high-purity chemical standard in analytical laboratories for method development, validation, and quality control testing of drug substances and products.
• Neuropsychiatric Drug Development: A vital compound for R&D targeting depression, anxiety, and other central nervous system disorders.
• Metabolism and Pharmacokinetics Studies: Essential for understanding the isomer-specific absorption, distribution, metabolism, and excretion (ADME) profiles.

Basic Information

Product Name	(E)-Doxepin Hydrochloride
CAS No.	4698-39-9
Molecular Formula	C19H22ClNO
Molecular Weight	315.84 g/mol
Synonyms	(E)-Doxepin HCl; (E)-11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin Hydrochloride; trans-Doxepin Hydrochloride; Doxepin (E)-Isomer Hydrochloride; NSC 108160; (E)-Isomer of Doxepin Hydrochloride; (E)-Doxepin Monohydrochloride
EINECS	Contact for details

Quality Control

Our (E)-Doxepin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤1.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.