Description

n-Carbobenzyloxy-L-Aspartic Anhydride is a protected amino acid derivative widely used as a key synthetic intermediate in organic and peptide chemistry. This compound is essential for the controlled synthesis of aspartic acid-containing peptides, enabling the formation of specific amide bonds while preventing unwanted side reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and fine chemicals. Its reliable performance makes it a critical reagent for chemists requiring high-purity building blocks for complex molecular assembly.

Application

• Peptide Synthesis: A crucial building block for the solid-phase and solution-phase synthesis of peptides containing aspartic acid residues.
• Pharmaceutical Intermediates: Serves as a key intermediate in the research and production of active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Used in the preparation of modified peptides and proteins for biochemical research and diagnostic applications.
• Protecting Group Chemistry: The carbobenzyloxy (Cbz) group provides orthogonal protection for the amine functionality during multi-step synthetic sequences.
• Academic & Industrial R&D: Employed in research laboratories for exploring new synthetic methodologies and creating custom peptide libraries.
• Fine Chemical Production: Integral to the manufacture of specialized, high-value chemicals for various advanced material and life science applications.

Basic Information

Product Name	n-Carbobenzyloxy-L-Aspartic Anhydride
CAS No.	4515-23-5
Molecular Formula	C12H11NO5
Molecular Weight	249.22 g/mol
Synonyms	N-Carbobenzyloxy-L-aspartic Anhydride; Cbz-L-Aspartic Acid Anhydride; N-Cbz-L-Aspartic Anhydride; (S)-4-((Benzyloxy)carbonylamino)-2,5-dioxotetrahydrofuran-3-carboxylic Acid; Z-L-Aspartic Acid Anhydride; N-Carbobenzoxy-L-aspartic Anhydride; Benzyl N-[(2S)-1,4-dioxo-1,4-dihydro-2,5-furandiyldicarbonyl]-L-aspartate; L-Aspartic Acid, N-[(phenylmethoxy)carbonyl]-, anhydride
EINECS	Contact for details

Quality Control

Our n-Carbobenzyloxy-L-Aspartic Anhydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.