Description

n-Benzyloxycarbonyl-L-Glutamic Anhydride is a protected amino acid derivative widely used as a key synthetic intermediate in peptide chemistry. Its primary value lies in enabling the controlled, sequential construction of peptide chains by protecting the glutamic acid side chain carboxyl group during synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing peptide-based therapeutics, diagnostic agents, and biochemical tools. The high-purity material ensures reliable coupling reactions and optimal yields in complex synthetic sequences.

Application

• Peptide Synthesis: A crucial building block for the solid-phase and solution-phase synthesis of peptides containing glutamic acid residues.
• Pharmaceutical Intermediates: Serves as a key precursor in the research and production of peptide drugs, including hormone analogs and enzyme inhibitors.
• Bioconjugation: Used to introduce glutamic acid moieties into larger biomolecules, proteins, or drug delivery systems.
• Research & Development: Employed in academic and industrial R&D for exploring new peptide structures and their biological activities.
• Custom Peptide Services: A fundamental reagent for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering custom peptide production.
• Prodrug Design: Utilized in the design of prodrugs where a peptide linker is required for targeted drug release.

Basic Information

Product Name	n-Benzyloxycarbonyl-L-Glutamic Anhydride
CAS No.	4124-76-9
Molecular Formula	C13H13NO5
Molecular Weight	263.25 g/mol
Synonyms	Z-L-Glu-Anhydride; N-Carbobenzoxy-L-glutamic Anhydride; Nα-Cbz-L-glutamic Anhydride; (S)-5-Oxo-4-(phenylmethoxycarbonylamino)-5-oxopentanoic acid; CBZ-L-Glutamic Acid Anhydride; N-Benzyloxycarbonyl-L-glutamic acid cyclic anhydride; N-CBZ-L-Glutamic Anhydride; Z-Glu-OH Anhydride
EINECS	223-925-9

Quality Control

Our n-Benzyloxycarbonyl-L-Glutamic Anhydride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical intermediates and advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Specific range provided on COA
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.