Description

D-Glucose-1-14C is a carbon-14 labeled isotopologue of D-glucose, a fundamental monosaccharide and primary energy source in biological systems. This radiolabeled compound is essential for metabolic pathway tracing and pharmacokinetic studies, providing critical insights into glucose utilization and turnover. It is a vital tool for researchers in pharmaceutical development, biochemistry, and metabolic disease research who require precise tracking of glucose molecules in complex biological systems.

Application

• Metabolic Flux Analysis (MFA): Tracing the fate of glucose carbons in central carbon metabolism to quantify pathway activities in cells and tissues.
• Drug Metabolism and Pharmacokinetics (DMPK): Studying the absorption, distribution, metabolism, and excretion (ADME) of glucose or glucose-conjugated drug candidates.
• Biochemical Research: Investigating specific enzymatic reactions, such as those catalyzed by hexokinase or glucose-6-phosphate dehydrogenase, in glycolysis and the pentose phosphate pathway.
• In Vivo Imaging and Biodistribution: Used in preclinical studies to visualize and quantify glucose uptake and localization in animal models, often relevant to cancer or metabolic disorder research.
• Diagnostic Agent Development: Serving as a precursor or reference standard in the development of novel diagnostic probes and imaging agents.
• Environmental & Agricultural Studies: Tracing carbon flow in microbial communities or plant systems to study soil health, nutrient cycling, and photosynthesis.

Basic Information

Product Name	D-Glucose-1-14C
CAS No.	4005-41-8
Molecular Formula	C6H12O6 (with 14C at position 1)
Molecular Weight	~180.16 g/mol (exact mass depends on 14C enrichment)
Synonyms	1-14C-D-Glucose; D-[1-14C]Glucose; [1-14C]Glucose; Glucose-1-14C; (1-14C)-D-Glucopyranose; Dextrose-1-14C; Blood Sugar-1-14C; Grape Sugar-1-14C; α-D-Glucopyranose-1-14C
EINECS	Contact for details

Quality Control

Every batch of D-Glucose-1-14C is manufactured and analyzed under strict quality control protocols to ensure identity, purity, and specific activity. Our products undergo rigorous testing, including HPLC, NMR, and radiochemical purity analysis, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing specific activity, radiochemical purity, chemical purity, and analytical methods is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider conditions recommended for radioactive materials, typically in a designated, shielded area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Specific Activity	50-62 mCi/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Solvent (for solutions)	Ethanol:Water (Contact for specific ratio)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.