Description

D-Ribose, [1-14C]- is a carbon-14 labeled isotopologue of the essential pentose sugar D-ribose, specifically labeled at the C-1 position. This compound is a critical tool for metabolic pathway tracing and pharmacokinetic studies, offering researchers a precise method to monitor ribose incorporation and utilization in biological systems. It is primarily utilized by scientists in pharmaceutical R&D, biochemistry, and metabolic research for investigating nucleotide synthesis, energy metabolism, and glycosylation processes.

Application

• Metabolic Flux Analysis (MFA): Tracing the incorporation of ribose into nucleotides, cofactors (e.g., ATP, NADH), and sugar nucleotides in cell cultures and animal models.
• Drug Metabolism and Pharmacokinetics (DMPK): Radiolabeled studies to determine the absorption, distribution, metabolism, and excretion (ADME) profiles of ribose-based pharmaceuticals or prodrugs.
• Biochemical Pathway Elucidation: Research into the pentose phosphate pathway, nucleotide salvage pathways, and glycosylation mechanisms.
• Autoradiography and Imaging: Used as a tracer in tissue-based studies to visualize sites of active ribose metabolism.
• Standards for Analytical Chemistry: Serving as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) or scintillation counting for quantitative analysis of ribose and its metabolites.

Basic Information

Item	Detail
Product Name	D-Ribose, [1-14C]-
CAS No.	4005-39-4
Molecular Formula	C5H1014CO5
Molecular Weight	~152.1 g/mol (for 14C labeled)
Synonyms	1-14C-D-Ribose; [1-14C]Ribose; D-(-)-Ribose-1-14C; (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal-1-14C; Ribose-1-14C; 1-Carbon-14 labeled D-ribose; D-Ribose-1-14C; Aldopentose-1-14C
EINECS	Contact for details

Quality Control

Every batch of D-Ribose, [1-14C]- is manufactured and analyzed under strict quality systems to ensure high radiochemical purity and chemical stability. Our quality control includes verification of specific activity, radiochemical purity by HPLC, and chemical identity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for radioactivity, purity, and solvent composition is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container in a dry, inert atmosphere. Follow all applicable radiation safety guidelines for handling and storage of radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/Co-Elution)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Chemical Purity (HPLC)	≥ 95%
Solvent (if supplied in solution)	Ethanol:Water (Specified on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.