Description

[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(6-Oxo-3H-Purin-9-Yl)Oxolan-2-Yl]Methox Yphosphonic Acid is a high-purity nucleotide analog of significant interest in advanced biochemical and pharmaceutical research. This compound serves as a critical building block and a potent inhibitor for studying nucleotide metabolism and enzyme function. It is essential for researchers and manufacturers in the fields of antiviral drug development, oncology research, and molecular biology, where precise chemical structure and high purity are paramount for reliable experimental and production outcomes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside-based antiviral and anticancer therapeutics.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for kinases, polymerases, and other nucleotide-processing enzymes.
• Proteomics & Molecular Biology: Employed in the study of signal transduction pathways and cellular metabolism regulation.
• Diagnostic Reagent Development: Component in the formulation of high-sensitivity assay kits for clinical and research diagnostics.
• Life Science Tools: Integral for creating labeled probes and other tools used in genetic analysis and drug discovery platforms.

Basic Information

Product Name	[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(6-Oxo-3H-Purin-9-Yl)Oxolan-2-Yl]Methox Yphosphonic Acid
CAS No.	485-83-6
Molecular Formula	C11H15N4O9P
Molecular Weight	378.23 g/mol
Synonyms	9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(methoxyphosphonyl)oxolan-2-yl]-3H-purin-6-one; 6-Oxo-PMPA; (R)-PMPA; Adefovir precursor; GS-7340 intermediate; (R)-9-[2-(Phosphonomethoxy)propyl]adenine analog; PMPA nucleoside
EINECS	Contact for details

Quality Control

Our production of this nucleotide analog adheres to stringent GMP and ISO 9001 guidelines to ensure batch-to-batch consistency and traceability. Each lot is subjected to comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and rigorous tests for residual solvents and heavy metals. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a dry environment to prevent moisture absorption, which can compromise stability. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.