Description

4-(Trifluoromethyl)Benzoic Acid is a versatile aromatic carboxylic acid derivative characterized by a trifluoromethyl substituent, offering unique electronic and steric properties. This compound is a critical pharmaceutical intermediate and building block in advanced organic synthesis, valued for its ability to modulate the lipophilicity and metabolic stability of target molecules. It is essential for R&D and production in the pharmaceutical, agrochemical, and material science industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system and inflammatory diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for electron-transport materials and ligands in electronic displays and lighting technologies.
• Polymer & Resin Modifier: Incorporated into specialty polymers to improve chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Employed in coupling reactions (e.g., Suzuki, Heck) and as a precursor for acid chlorides, esters, and amides in fine chemical manufacturing.
• Metal-Organic Framework (MOF) Construction: Acts as a functional linker to create porous materials for gas storage, separation, and catalysis.

Basic Information

Product Name	4-(Trifluoromethyl)Benzoic Acid
CAS No.	455-24-3
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	alpha,alpha,α-Trifluoro-p-toluic Acid; p-(Trifluoromethyl)benzoic Acid; 4-(Trifluoromethyl)benzenecarboxylic Acid; Benzoic acid, 4-(trifluoromethyl)-; PTFBA; p-Carboxybenzotrifluoride; 4-Carboxybenzotrifluoride; p-Trifluoromethylbenzoic Acid
EINECS	207-247-9

Quality Control

Our 4-(Trifluoromethyl)Benzoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Our production adheres to cGMP guidelines where applicable, ensuring reliability for critical pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	160 - 164 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.