Description

4-Fluoro-3-Nitrobenzoic Acid is a versatile aromatic building block characterized by its benzoic acid core substituted with both fluorine and nitro groups. This unique structure makes it a critical intermediate for synthesizing more complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by research chemists and process development teams for creating active pharmaceutical ingredients (APIs), advanced materials, and specialty dyes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various drug candidates and active pharmaceutical ingredients (APIs), leveraging its reactive nitro and carboxylic acid groups for further functionalization.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, pesticides, and fungicides, where the fluorine atom can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and advanced organic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate in the production of complex azo dyes and other high-performance colorants.
• Organic Synthesis & Chemical Research: Employed in academic and industrial R&D labs for constructing complex molecular architectures, including heterocyclic compounds.
• Cross-Coupling Reactions: The carboxylic acid group allows for easy conversion to acid chlorides or esters, making it a suitable substrate for palladium-catalyzed coupling reactions.

Basic Information

Product Name	4-Fluoro-3-Nitrobenzoic Acid
CAS No.	453-71-4
Molecular Formula	C7H4FNO4
Molecular Weight	185.11 g/mol
Synonyms	3-Nitro-4-fluorobenzoic Acid; 4-Fluoro-3-nitrobenzoic Acid; Benzoic acid, 4-fluoro-3-nitro-; 4-Fluoro-3-nitro-benzoic acid; 3-Nitro-4-fluorobenzoic acid; 4-Fluoro-3-nitrobenzoic acid; 453-71-4; NSC 403119
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Nitrobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	155°C - 160°C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.