Description

Azathioprine is a potent immunosuppressive agent belonging to the purine analogue class of pharmaceuticals. Its primary value lies in its ability to modulate the immune system, making it a cornerstone therapeutic for preventing organ transplant rejection and managing autoimmune disorders. This active pharmaceutical ingredient (API) is essential for manufacturers in the pharmaceutical and biotechnology sectors developing critical immunosuppressive therapies.

Application

• Immunosuppressive Drug Formulation: Primary active ingredient in oral tablets and injectable formulations for organ transplantation (kidney, heart, liver).
• Autoimmune Disease Management: Key component in medications for treating rheumatoid arthritis, systemic lupus erythematosus (SLE), Crohn's disease, and ulcerative colitis.
• Dermatological Treatments: Used in therapies for severe, treatment-resistant conditions like pemphigus vulgaris and atopic dermatitis.
• Hematological Disorder Therapy: Employed in the treatment of certain autoimmune hemolytic anemias and idiopathic thrombocytopenic purpura (ITP).
• Research & Development: Serves as a critical reference standard and biochemical tool in immunological and pharmacological research.
• Veterinary Pharmaceuticals: Used in veterinary medicine for managing autoimmune conditions in companion animals.

Basic Information

Item	Detail
Product Name	Azathioprine
CAS No.	446-86-6
Molecular Formula	C9H7N7O2S
Molecular Weight	277.27 g/mol
Synonyms	Azathioprine; 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine; Azamun; Azanin; Imuran; Azapress; Azasan; Imurel; AZA; BW 57-322
EINECS	207-175-4

Quality Control

Our Azathioprine is manufactured under strict quality systems to meet the rigorous standards of the global pharmaceutical industry. Each batch is tested to ensure compliance with major pharmacopoeial specifications, including USP and EP monographs. A comprehensive Certificate of Analysis (COA) is provided for every shipment, detailing purity, identity, and impurity profiles to guarantee batch-to-batch consistency and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Pale yellow to yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Related Substances (HPLC)	Total impurities NMT 1.0% Any individual impurity NMT 0.5%
Microbial Enumeration	Meets USP <61> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.