Description

2-(Trifluoromethyl)Benzoic Acid is a versatile fluorinated aromatic carboxylic acid, valued for its unique combination of a strong electron-withdrawing trifluoromethyl group and a reactive carboxylic acid functionality. This compound is a critical building block in advanced organic synthesis, particularly for introducing lipophilicity and metabolic stability into target molecules. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and high-performance materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in protease inhibitors, anti-inflammatory drugs, and other therapeutics where the trifluoromethyl group enhances bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where its structural motif contributes to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated monomers and ligands used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into polymer chains to alter physical properties such as chemical resistance, thermal stability, and surface characteristics.
• Coordination Chemistry & Ligand: Acts as a ligand for metal complexes in catalysis and material science applications.
• General Organic Synthesis: Employed in various name reactions (e.g., Suzuki coupling, amidation) to create complex, fluorinated aromatic compounds for research and development.

Basic Information

Item	Details
Product Name	2-(Trifluoromethyl)Benzoic Acid
CAS No.	433-97-6
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	α,α,α-Trifluoro-o-toluic Acid; 2-Trifluoromethylbenzoic Acid; o-(Trifluoromethyl)benzoic Acid; Benzoic acid, 2-(trifluoromethyl)-; 2-Carboxybenzotrifluoride; o-Trifluoromethylbenzoic Acid; 2-TFMBA; TFMBA
EINECS	207-101-8

Quality Control

Our 2-(Trifluoromethyl)Benzoic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and titration methods, to ensure high purity and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for all shipments, supporting compliance with cGMP and ISO 9001 standards for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	102 - 106 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.