Description

2-Amino-4-(Trifluoromethyl)Benzoic Acid is a high-value trifluoromethylated benzoic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both an amino and a carboxylic acid functional group adjacent to a trifluoromethyl moiety, makes it indispensable for creating compounds with enhanced biological activity and physicochemical properties. This intermediate is primarily sought after by the pharmaceutical, agrochemical, and specialty chemical industries for research and development, as well as process-scale manufacturing.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Employed in the synthesis of advanced polymers, liquid crystals, and organic electronic materials.
• Fluorinated Compound Research: Essential for academic and industrial R&D focused on introducing fluorine atoms into complex molecules to modulate their properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke chemical entities.

Basic Information

Product Name	2-Amino-4-(Trifluoromethyl)Benzoic Acid
CAS No.	402-13-1
Molecular Formula	C8H6F3NO2
Molecular Weight	205.14 g/mol
Synonyms	4-(Trifluoromethyl)anthranilic acid; 2-Amino-α,α,α-trifluoro-p-toluic acid; Benzoic acid, 2-amino-4-(trifluoromethyl)-; 4-Trifluoromethylanthranilic acid; 2-Amino-4-trifluoromethylbenzoic acid; 2-Carboxy-5-(trifluoromethyl)aniline; 5-(Trifluoromethyl)anthranilic acid
EINECS	206-937-2

Quality Control

Our 2-Amino-4-(Trifluoromethyl)Benzoic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, and we can support custom specifications for cGMP or other regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.