Description

E-Retinoylb-Glucuronide is a specific glucuronide conjugate of retinoic acid, representing a key metabolite in the retinoid pathway. This compound is of significant interest for its role in modulating retinoid activity and transport, offering a more soluble and potentially less toxic alternative to the parent compound. It is primarily utilized by researchers and manufacturers in the pharmaceutical, nutraceutical, and advanced cosmetic sectors for developing novel therapeutics and bioactive formulations.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolite Research: Critical for in vitro and in vivo studies investigating the metabolic fate, bioavailability, and detoxification pathways of retinoids like retinoic acid (Tretinoin).
• Cosmeceutical Actives: Incorporated into advanced skincare formulations targeting photoaging and cellular renewal, leveraging its modified retinoid activity.
• Biochemical Reagent: Serves as a substrate or inhibitor in enzymatic assays studying UDP-glucuronosyltransferases (UGTs) and other conjugation enzymes.
• Nutraceutical Development: Explored for use in specialized dietary supplements aimed at supporting skin health and cellular function with improved tolerability profiles.

Basic Information

Item	Detail
Product Name	E-Retinoylb-Glucuronide
CAS No.	401-10-5
Molecular Formula	C₂₆H₃₄O₉
Molecular Weight	490.54 g/mol
Synonyms	Retinoyl-β-glucuronide; all-trans-Retinoyl-β-D-glucuronide; Retinoic Acid Glucuronide; Tretinoin Glucuronide; Retinoyl Glucuronide; β-Glucuronide of Retinoic Acid; E-Retinoyl-β-glucuronide; Vitamin A Acid Glucuronide
EINECS	Contact for details

Quality Control

Our E-Retinoylb-Glucuronide is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation (NMR, IR) to ensure it meets exacting standards for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.