Description

Avibactam Sodium Isomer is a critical pharmaceutical intermediate and reference standard, specifically the sodium salt of a key structural isomer of the β-lactamase inhibitor avibactam. This compound is essential for research and development in the field of antibiotic resistance, providing a precise tool for studying enzyme inhibition mechanisms and developing new combination therapies. It is primarily required by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) focused on next-generation antibacterial agents.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for analytical method development, validation, and quality control (QC) testing in API and finished drug product manufacturing.
• Biochemical Research: Serves as a key reagent in enzymatic studies to investigate the inhibition kinetics and binding modes of β-lactamase enzymes, aiding in the understanding of antibiotic resistance.
• Process Chemistry & Development: Employed as an intermediate or a comparative marker in the synthetic pathway development and optimization for novel β-lactamase inhibitor drugs.
• Academic Research: Utilized in university and institutional labs for fundamental research on bacterial resistance mechanisms and the discovery of new therapeutic agents.
• Regulatory Submissions: Provides essential characterization data and impurity profiles for regulatory filings (e.g., with FDA, EMA) for new drug applications.

Basic Information

Product Name	Avibactam Sodium Isomer
CAS No.	396731-20-7
Molecular Formula	C7H10N3NaO6S
Molecular Weight	287.23 g/mol
Synonyms	(1R,2S,5R)-2-[(2S,5R)-2-Carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl]oxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylate Sodium Salt; NXL-104 Sodium Salt Isomer; AVIBASTAT Sodium Isomer; Sodium [(1R,2S,5R)-2-{[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl]oxy}-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl]formate
EINECS	Contact for details

Quality Control

Our Avibactam Sodium Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for isomeric composition, and stringent control of residual solvents and impurities to meet the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring full traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Isomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.