Description

Methyl(((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl) (Phenoxy)Phosphoryl)-L-Alaninate Fumarate is a high-purity, chemically defined nucleotide analog prodrug with significant pharmaceutical relevance. This compound is valued for its role as a key intermediate or active pharmaceutical ingredient (API) in the development of antiviral and anticancer therapeutics. It is primarily required by research institutions, pharmaceutical R&D laboratories, and manufacturers engaged in the synthesis of nucleoside-based drugs targeting viral polymerases.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of advanced nucleoside analog prodrugs.
• Antiviral Drug Research: Used in the development of therapeutics targeting viruses such as hepatitis B (HBV), hepatitis C (HCV), and other viral infections.
• Oncology Research: Investigated as a component in prodrug formulations designed for targeted cancer chemotherapy.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and polymerase function.
• Preclinical & Clinical Development: Supplied for use in formulation studies, pharmacokinetic profiling, and toxicity assessments during drug development pipelines.

Basic Information

Product Name	Methyl(((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl) (Phenoxy)Phosphoryl)-L-Alaninate Fumarate
CAS No.	390409-27-5
Molecular Formula	C22H27N6O8P
Molecular Weight	534.46 g/mol
Synonyms	GS-7340 Fumarate; Tenofovir Alafenamide Fumarate Intermediate; (R)-PMPA Pr Fumarate; (R)-9-[2-[[[[(1-Methoxycarbonyl)ethyl]phenoxyphosphinyl]methoxy]propyl]adenine Fumarate; TAFA Fumarate; GS-7340 Hemifumarate; Tenofovir Alafenamide Hemifumarate; Gilead Sciences Compound GS-7340 Fumarate
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent quality systems. Every batch is characterized and released according to comprehensive specifications, including identity confirmation by spectroscopic methods (NMR, IR, MS), high-purity assay by HPLC (typically ≥98.0%), and strict control of related substances and residual solvents. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.