Description

Curcumin Glucuronide is a major water-soluble metabolite of the bioactive polyphenol curcumin. This compound matters for researchers and formulators seeking to understand and harness the systemic bioavailability and biological activity of curcumin in vivo. It is primarily needed by the pharmaceutical, nutraceutical, and life science research industries for pharmacokinetic studies, metabolite reference standards, and the development of enhanced bioavailability formulations.

Application

• Pharmacokinetic and Metabolism Research: Serves as a critical reference standard for quantifying curcumin metabolites in plasma, urine, and tissue samples.
• Bioavailability Enhancement Studies: Used in comparative studies to evaluate the efficacy of different curcumin delivery systems (e.g., nanoparticles, phospholipid complexes).
• In Vitro Biological Activity Screening: Employed to investigate the direct antioxidant, anti-inflammatory, or other pharmacological effects of the glucuronidated metabolite.
• Analytical Method Development: Essential for calibrating and validating HPLC, LC-MS, and other analytical methods in bioanalytical laboratories.
• Nutraceutical Formulation: Potential use in advanced dietary supplements where specific metabolites are targeted for health benefits.
• Drug Discovery & Development: Acts as a key compound in ADME (Absorption, Distribution, Metabolism, Excretion) studies for curcumin-based drug candidates.

Basic Information

Product Name	Curcumin Glucuronide
CAS No.	387818-26-0
Molecular Formula	C27H28O14
Molecular Weight	576.5 g/mol
Synonyms	Curcumin 4'-O-β-D-Glucuronide; Curcumin Glucuronide; Curcumin-4'-O-glucuronide; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione 4'-Glucuronide; Curcumin Monoglucuronide; Curcumin Metabolite M1; (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione 4'-O-β-D-glucopyranosiduronic acid
EINECS	Contact for details

Quality Control

Our Curcumin Glucuronide is produced and tested under strict quality management protocols. Each batch undergoes comprehensive analysis, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to air and humidity.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.