Description

Ethyl(((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl) (Phenoxy)Phosphoryl)-L-Alaninate Fumarate is a high-purity, nucleoside-based prodrug compound designed for advanced pharmaceutical research and development. This molecule is critical for its role as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel antiviral and anticancer therapeutics. It is primarily sought by pharmaceutical manufacturers, biotechnology R&D laboratories, and academic research institutions focused on nucleotide analog drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of next-generation antiviral medications.
• Antiviral Drug Development: Used in R&D for prodrugs targeting viral polymerases, particularly in hepatitis and HIV research.
• Oncology Research: Investigated as a component in nucleotide analog therapies designed to inhibit cancer cell proliferation.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies involving nucleotide metabolism.
• Preclinical & Clinical Trial Material: Supplied as a high-grade material for non-clinical studies and early-phase clinical manufacturing.
• Process Chemistry & Scale-Up: Used in developing and optimizing scalable synthetic routes for commercial API production.

Basic Information

Product Name	Ethyl(((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl) (Phenoxy)Phosphoryl)-L-Alaninate Fumarate
CAS No.	382140-25-2
Molecular Formula	C23H29N6O8P
Molecular Weight	548.48 g/mol
Synonyms	GS-7340 Fumarate; Tenofovir Alafenamide Fumarate Intermediate; (R)-PMPA Pr Fumarate; TAFA Fumarate; (R)-9-[2-[[[(S)-1-(Ethoxycarbonyl)ethyl]phenoxyphosphinyl]methoxy]propyl]adenine Fumarate; GS-7340 Hemifumarate; Tenofovir Alafenamide Hemifumarate; BMS-986001 Fumarate Intermediate
EINECS	Contact for details

Quality Control

Our Ethyl(((((R)-1-(6-Amino-9H-Purin-9-Yl)Propan-2-Yl)Oxy)Methyl) (Phenoxy)Phosphoryl)-L-Alaninate Fumarate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent pharmaceutical-grade specifications, including identity, purity, and impurity profile verification. Certificates of Analysis (COA) detailing results from HPLC, NMR, and MS are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.