Description

Tenofovir Alafenamide Fumarate is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API). This compound is a key prodrug form of tenofovir, designed for enhanced cellular uptake and reduced systemic exposure. It is critically required by pharmaceutical manufacturers and research institutions for the development and production of next-generation antiviral medications. The material is supplied under stringent quality control to meet the demands of GMP manufacturing.

Application

• Primary Active Pharmaceutical Ingredient (API) in antiviral drug formulations.
• Critical intermediate for the synthesis of Hepatitis B Virus (HBV) and Human Immunodeficiency Virus (HIV) treatments.
• Key component in fixed-dose combination (FDC) therapies for improved patient compliance.
• Reference standard for analytical method development and quality control laboratories.
• Research chemical for preclinical and clinical studies in virology and pharmacology.
• Starting material for the development of novel prodrugs and targeted delivery systems.

Basic Information

Product Name	Tenofovir Alafenamide Fumarate
CAS No.	379270-38-9
Molecular Formula	C21H29FN6O5 • C4H4O4
Molecular Weight	534.5 g/mol
Synonyms	TAF Fumarate; GS-7340 Fumarate; Tenofovir Alafenamide Hemifumarate; (R)-PMPA Prodrug Fumarate; 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine Fumarate; Gilead Sciences 7340; Vemlidy® API
EINECS	Contact for details

Quality Control

Our Tenofovir Alafenamide Fumarate is manufactured under a quality management system designed for pharmaceutical applications. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with ICH Q7, GMP guidelines, and relevant pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. Ensure the storage area is well-ventilated and away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Individual Unknown Impurity	≤ 0.10%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.