Description

Tenofovir Alafenamide CAS NO 379270-37-8 is a high-purity pharmaceutical intermediate and prodrug of tenofovir, designed for enhanced cellular delivery and reduced systemic exposure. This compound is of critical importance for the development and production of next-generation antiviral therapies, offering improved safety and efficacy profiles. It is primarily required by pharmaceutical manufacturers and research organizations engaged in antiviral drug formulation, particularly for HIV and hepatitis B treatments.

Application

• Active Pharmaceutical Ingredient (API) synthesis for antiviral medications.
• Pharmaceutical Research & Development for novel antiviral prodrug formulations.
• Key intermediate in the manufacture of fixed-dose combination (FDC) drugs for HIV treatment.
• Reference standard for quality control and analytical testing in pharmaceutical laboratories.
• Process development and scale-up activities for GMP-compliant production.
• Academic and clinical research into nucleotide reverse transcriptase inhibitors (NRTIs).

Basic Information

Product Name	Tenofovir Alafenamide
CAS No.	379270-37-8
Molecular Formula	C21H29FN6O5P
Molecular Weight	476.46 g/mol
Synonyms	TAF; GS-7340; Tenofovir Alafenamide Fumarate (salt form); (R)-((S)-1-(6-Aminopurin-9-yl)propan-2-yloxy)methylphosphonic acid isopropyloxycarbonyloxymethyl ester; PMPA Pr; Gilead Sciences 7340; Tenofovir AF; 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethoxy]methoxy]phosphinoyl]methoxy]propyl]adenine
EINECS	Contact for details

Quality Control

Our Tenofovir Alafenamide is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch undergoes rigorous analytical testing to ensure compliance with high-purity standards, including identity, purity, and impurity profile verification. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications and test results. We support development with material suitable for research through to GMP-grade production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccated environment to maintain stability and potency. Avoid prolonged exposure to high humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.