Description

Maraviroc CAS NO 376348-65-1 is a selective CCR5 antagonist, a small molecule pharmaceutical active ingredient of significant therapeutic importance. It is a critical component in antiretroviral therapy, specifically designed to block viral entry into host cells. This compound is essential for pharmaceutical manufacturers and research institutions developing treatments for HIV-1 infection, particularly for patients with CCR5-tropic virus.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key therapeutic component in finished dosage forms for HIV treatment.
• Antiretroviral Therapy: Formulation into tablets and other oral solid dosage forms for combination therapy regimens.
• HIV-1 Research: Used as a reference standard and investigational compound in virology and immunology research.
• Drug Development: Serves as a model compound for developing new entry inhibitors and studying CCR5 receptor mechanisms.
• Clinical Trial Material (CTM): Supplied under GMP conditions for use in clinical studies and bioequivalence testing.
• Generic Drug Manufacturing: Sourced by generic pharmaceutical companies for the production of approved therapeutic equivalents.

Basic Information

Product Name	Maraviroc
CAS No.	376348-65-1
Molecular Formula	C₂₉H₄₁F₂N₅O
Molecular Weight	513.66 g/mol
Synonyms	4,4-Difluoro-N-{(1S)-3-[3-exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide; UK-427,857; Celsentri; Selzentry; Maraviroc hydrate; CCR5 Antagonist UK-427,857; (1S)-N-{(1S)-3-[3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}-4,4-difluorocyclohexanecarboxamide
EINECS	Contact for details

Quality Control

Our Maraviroc is manufactured under strict quality systems to ensure it meets the rigorous standards required for pharmaceutical use. We provide material that complies with relevant pharmacopeial monographs (e.g., USP, EP) where applicable. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, ensuring full traceability and regulatory compliance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.