Description

16Beta-Hydroxy-17Beta-Estradiol-2,4-D2 is a high-purity, deuterated derivative of the endogenous estrogen, 17β-estradiol. This compound is specifically designed for use as a critical internal standard in advanced analytical techniques, ensuring precise quantification and method validation. It is essential for researchers and quality control laboratories in the pharmaceutical, clinical research, and forensic toxicology sectors who require the highest levels of accuracy in steroid hormone analysis.

Application

• Liquid Chromatography-Mass Spectrometry (LC-MS/MS) Internal Standard: Primary application for the accurate quantification of endogenous estradiol and related metabolites in complex biological matrices.
• Pharmaceutical Research & Development: Used in pharmacokinetic and pharmacodynamic studies to track drug metabolism and hormone levels.
• Clinical Diagnostics: Enables reliable measurement of estradiol in serum and plasma for endocrine disorder assessment and fertility monitoring.
• Forensic and Doping Control Analysis: Critical for confirming the presence of endogenous steroids and detecting their abuse in sports.
• Metabolomics and Biomarker Discovery: Serves as a stable isotope-labeled tracer in metabolic pathway studies.
• Method Development and Validation: Provides a reference for establishing selectivity, sensitivity, and reproducibility in new analytical protocols.

Basic Information

Product Name	16Beta-Hydroxy-17Beta-Estradiol-2,4-D2
CAS No.	366495-94-5
Molecular Formula	C18H22D2O3
Molecular Weight	290.40 g/mol
Synonyms	16β-Hydroxy-17β-estradiol-2,4-d2; Estra-1,3,5(10)-triene-3,16β,17β-triol-2,4-d2; [2,4-D2]-16β-Hydroxyestradiol; Deuterated 16β-Hydroxyestradiol; 16β-Hydroxyestra-1,3,5(10)-triene-3,17β-diol-2,4-d2; 3,16β,17β-Trihydroxyestra-1,3,5(10)-triene-2,4-d2
EINECS	Contact for details

Quality Control

Every batch of 16Beta-Hydroxy-17Beta-Estradiol-2,4-D2 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic methods. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and identification is provided with each shipment to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the product label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.