Description

(R)-(-)-4,12-Bis(Diphenylphosphino)-(2.2)-Paracyclophane is a highly specialized chiral diphosphine ligand, a crucial component in asymmetric catalysis. Its unique paracyclophane backbone provides a rigid, three-dimensional environment that is essential for inducing high enantioselectivity in transition metal-catalyzed reactions. This compound is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries for the development of chiral active pharmaceutical ingredients (APIs) and other high-value enantiopure compounds.

Application

• As a chiral ligand for asymmetric hydrogenation reactions, particularly for the synthesis of amino acids and their derivatives.
• In asymmetric C-C bond-forming reactions, such as cross-coupling and allylic substitution, for constructing complex chiral molecules.
• For the development of novel transition metal catalysts used in the production of enantiomerically pure pharmaceuticals.
• In academic and industrial R&D for exploring new methodologies in stereoselective synthesis.
• As a key reagent in the synthesis of chiral intermediates for agrochemicals and specialty chemicals.

Basic Information

Product Name	(R)-(-)-4,12-Bis(Diphenylphosphino)-(2.2)-Paracyclophane
CAS No.	364732-88-7
Molecular Formula	C40H32P2
Molecular Weight	574.63 g/mol
Synonyms	(R)-(-)-4,12-Bis(diphenylphosphino)[2.2]paracyclophane; (R)-(-)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane; (R)-PhanePhos; (R)-4,12-Bis(diphenylphosphino)[2.2]paracyclophane; (R)-BDPP; (R)-(-)-BDPP; (R)-(-)-4,12-Bis(diphenylphosphino)-(2.2)-paracyclophane; (R)-(-)-4,12-Bis(diphenylphosphino)[2.2]paracyclophane
EINECS	Contact for details

Quality Control

Our (R)-(-)-4,12-Bis(Diphenylphosphino)-(2.2)-Paracyclophane is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral HPLC, 31P NMR, and 1H NMR, to ensure high chemical and chiral purity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee batch-to-batch consistency and support your regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.