Description

4-(Bromomethyl)-3-Fluorobenzoicacid CAS NO 361456-46-4 is a high-purity fluorinated aromatic building block, essential for introducing both bromomethyl and carboxylic acid functionalities in advanced synthesis. This compound is critical for pharmaceutical and agrochemical research, enabling the precise construction of complex molecules. It is primarily sought by R&D chemists and process development scientists in the life sciences and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging the fluorinated aromatic core for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Monomer: A functional monomer for synthesizing specialty polymers with unique optical or electronic properties.
• Chemical Biology Probe Synthesis: Employed to create fluorescent tags or covalent inhibitors for target identification and validation studies.
• Cross-Coupling Reactions: The bromomethyl group is a versatile handle for further functionalization via Suzuki, Sonogashira, or Buchwald-Hartwig couplings.

Basic Information

Product Name	4-(Bromomethyl)-3-Fluorobenzoicacid
CAS No.	361456-46-4
Molecular Formula	C8H6BrFO2
Molecular Weight	233.04 g/mol
Synonyms	3-Fluoro-4-(bromomethyl)benzoic acid; 4-(Bromomethyl)-3-fluorobenzoic acid; Benzoic acid, 4-(bromomethyl)-3-fluoro-; 361456-46-4; 3-Fluoro-4-bromomethylbenzoic acid; 4-Bromomethyl-3-fluorobenzoic acid; 3-Fluoro-4-(bromomethyl)benzoic acid
EINECS	Contact for details

Quality Control

Our 4-(Bromomethyl)-3-Fluorobenzoicacid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.