Description

(R)-(-)-1-[(S)-2-(Di(3,5-Dimethyl-4-Methoxyphenyl)Phosphino)Ferrocenyl]Ethyldicyclohexylphosphine is a highly specialized, chiral ferrocenyl phosphine ligand crucial for asymmetric catalysis. This compound matters because it enables the precise stereochemical control required for synthesizing enantiomerically pure pharmaceutical intermediates and fine chemicals. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-performance ligands for transition-metal catalyzed reactions such as hydrogenation, cross-coupling, and hydroformylation.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical API synthesis.
• Cross-Coupling Reactions: Used in asymmetric Suzuki-Miyaura, Heck, and Negishi couplings to construct chiral biaryl and C-C bonds.
• Hydroformylation Processes: Facilitates the production of chiral aldehydes from olefins with high regio- and enantioselectivity.
• Academic & Process R&D: Serves as a critical tool for developing new catalytic methodologies and optimizing synthetic routes in laboratory research.
• Agrochemical Synthesis: Employed in the manufacture of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Chiral Auxiliary Preparation: Used in the synthesis of other chiral ligands and organocatalysts.

Basic Information

Product Name	(R)-(-)-1-[(S)-2-(Di(3,5-Dimethyl-4-Methoxyphenyl)Phosphino)Ferrocenyl]Ethyldicyclohexylphosphine
CAS No.	360048-63-1
Molecular Formula	C47H56FeO2P2
Molecular Weight	770.72 g/mol
Synonyms	(R)-(-)-1-[(S)-2-(Di(3,5-dimethyl-4-methoxyphenyl)phosphino)ferrocenyl]ethyldicyclohexylphosphine; Josiphos SL-J009-1; (R)-1-[(S)-2-[Bis(3,5-dimethyl-4-methoxyphenyl)phosphino]ferrocenyl]ethyldicyclohexylphosphine; (R)-1-[(S)-2-(Di(3,5-dimethyl-4-methoxyphenyl)phosphino)ferrocenyl]ethyldicyclohexylphosphine; Chiral Josiphos Derivative; Ferrocenyl Diphosphine Ligand J009; SL-J009-1; (R)-1-[(S)-2-[Di(3,5-dimethyl-4-methoxyphenyl)phosphino]ferrocenyl]ethyldicyclohexylphosphine
EINECS	Contact for details

Quality Control

Our production of (R)-(-)-1-[(S)-2-(Di(3,5-Dimethyl-4-Methoxyphenyl)Phosphino)Ferrocenyl]Ethyldicyclohexylphosphine adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized by NMR (1H, 31P, 13C), HPLC, and specific optical rotation analysis to confirm identity and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Specific Optical Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.