Description

Threo-Hydroxy Bupropion Hcl CAS NO 357637-18-4 is a key pharmaceutical intermediate and metabolite of the antidepressant drug bupropion. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers engaged in the development of central nervous system (CNS) active pharmaceuticals and their generic versions.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in bioanalytical studies.
• Metabolite Research: Critical for in-vitro and in-vivo studies to understand the metabolic pathway, efficacy, and safety profile of Bupropion.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial intermediate in the synthetic pathway for producing Bupropion hydrochloride and related analogs.
• Pharmacokinetic Studies: Utilized in clinical and non-clinical trials to measure plasma concentration and determine the pharmacokinetic parameters of the metabolite.
• Academic and Institutional Research: Supports fundamental neuropharmacology and medicinal chemistry research in academic settings.

Basic Information

Product Name	Threo-Hydroxy Bupropion Hcl
CAS No.	357637-18-4
Molecular Formula	C13H19ClNO2 • HCl
Molecular Weight	294.21 g/mol (for free base: 258.75 g/mol)
Synonyms	(2R,3R)-2-(tert-Butylamino)-3'-chloropropiophenone hydrochloride; (2R,3R)-Hydroxybupropion hydrochloride; (R,R)-Hydroxybupropion HCl; BW 306U hydrochloride; Threo-dihydrobupropion hydrochloride; 1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanol hydrochloride (threo-); AH 5152 hydrochloride; Amfebutamone metabolite hydrochloride.
EINECS	Contact for details

Quality Control

Our Threo-Hydroxy Bupropion Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for isomeric composition, and comprehensive identification tests, to ensure it meets high-purity standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (Threo isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.