Description

L-Valine, n-Acetyl (15N) is a stable isotope-labeled derivative of the essential amino acid L-Valine, where the nitrogen atom is enriched with the 15N isotope. This specific labeling is critical for advanced research applications requiring precise metabolic tracing and structural elucidation using techniques like Nuclear Magnetic Resonance (NMR) spectroscopy and Mass Spectrometry (MS). It is an indispensable tool for scientists in pharmaceutical R&D, biochemistry, and metabolic studies who require high-purity, isotopically defined compounds for accurate and reliable experimental data.

Application

• Metabolic Pathway Tracing: Used as a 15N-labeled tracer in in vivo and in vitro studies to investigate amino acid metabolism, protein synthesis rates, and nitrogen flux in biological systems.
• Biomolecular NMR Spectroscopy: Essential for the structural and dynamic analysis of proteins and peptides, enabling residue-specific assignment and the study of protein-ligand interactions.
• Mass Spectrometry (MS) Standards: Serves as an internal standard for the accurate quantification of valine and its metabolites in complex biological samples via LC-MS/MS or GC-MS.
• Pharmaceutical Research: Employed in the development and testing of new drugs, particularly those targeting amino acid metabolism or requiring isotopic labeling for pharmacokinetic studies.
• Nutritional Science Research: Used in studies to understand protein utilization, amino acid requirements, and metabolic disorders related to branched-chain amino acids.

Basic Information

Product Name	L-Valine, n-Acetyl (15N)
CAS No.	355808-21-8
Molecular Formula	C7H1315NO3
Molecular Weight	160.18 g/mol (for 15N)
Synonyms	N-Acetyl-L-valine-15N; (2S)-2-Acetamido-3-methylbutanoic acid-15N; Ac-Val-15N-OH; L-Valine-15N, N-acetyl-; N-Acetyl-L-valine (nitrogen-15); N-Acetylvaline-15N; 15N Labeled N-Acetyl-L-valine
EINECS	Contact for details

Quality Control

Our L-Valine, n-Acetyl (15N) is produced under strict quality-controlled conditions to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (15N atom %), chemical purity (by HPLC), chiral purity, and moisture content. We adhere to cGMP guidelines where applicable to support regulatory filings in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
15N Isotopic Enrichment	≥ 98 atom % 15N
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% L-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.