Description

(2S,3S)-3-Hydroxy-2-Pyrrolidinemethanol is a high-purity, chiral pyrrolidine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its defined stereochemistry and bifunctional nature, making it an essential intermediate for constructing complex molecules with high enantiomeric purity. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for applications in asymmetric synthesis and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiomerically pure drugs, particularly for neurological and antiviral targets.
• Asymmetric Catalysis: Used as a precursor for chiral ligands and organocatalysts in stereoselective transformations.
• Agrochemical Research: Employed in the development of novel, stereospecific pesticides and herbicides.
• Academic & Industrial R&D: Serves as a versatile building block in medicinal chemistry and process development laboratories.
• Peptidomimetics: Incorporated into the backbone of peptide analogs to modulate biological activity and stability.
• Fine Chemical Synthesis: Used in the custom synthesis of specialty chemicals and advanced materials requiring specific chirality.

Basic Information

Product Name	(2S,3S)-3-Hydroxy-2-Pyrrolidinemethanol
CAS No.	350592-84-6
Molecular Formula	C5H11NO2
Molecular Weight	117.15 g/mol
Synonyms	(2S,3S)-2-(Hydroxymethyl)-3-pyrrolidinol; (3S,4S)-4-(Hydroxymethyl)-3-pyrrolidinol; (2S,3S)-3-Hydroxy-2-pyrrolidinemethanol; (2S,3S)-2-Pyrrolidinemethanol, 3-hydroxy-; (3S,4S)-3-Hydroxy-4-(hydroxymethyl)pyrrolidine; L-threo-3,4-Dihydroxypyrrolidine; (2S,3S)-3-Hydroxy-2-(hydroxymethyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (2S,3S)-3-Hydroxy-2-Pyrrolidinemethanol is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. We employ advanced analytical techniques, including chiral HPLC and NMR, to verify identity and purity. Certificates of Analysis (COA) detailing specific parameters such as assay, enantiomeric excess, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.