Description

(R)-2-Diphenyphosphino-2'-Phenyl-1,1'-Binaphthyl CAS NO 348617-10-7 is a high-value, chiral monophosphine ligand widely recognized for its pivotal role in asymmetric catalysis. Its significance lies in its ability to induce high enantioselectivity in a variety of transition metal-catalyzed reactions, enabling the production of single-enantiomer compounds with critical precision. This ligand is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable and effective tools for asymmetric synthesis.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones to produce chiral intermediates for active pharmaceutical ingredients (APIs).
• Asymmetric Cross-Coupling Reactions: Employed in C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, to construct complex chiral molecules.
• Asymmetric Allylic Substitution: Facilitates the creation of stereogenic centers via nucleophilic attack on allylic substrates with high regio- and enantiocontrol.
• Hydrosilylation and Hydroboration: Used to catalyze the enantioselective addition of Si-H or B-H bonds to unsaturated substrates.
• Pharmaceutical Intermediate Synthesis: Critical for the development of chiral drugs, including those for cardiovascular, central nervous system, and metabolic diseases.
• Agrochemical Active Ingredient Production: Enables the synthesis of enantiomerically pure herbicides, fungicides, and insecticides.
• Academic and Industrial R&D: A valuable tool for methodological development and exploring new asymmetric transformations in both academic and corporate research laboratories.

Basic Information

Product Name	(R)-2-Diphenyphosphino-2'-Phenyl-1,1'-Binaphthyl
CAS No.	348617-10-7
Molecular Formula	C38H27P
Molecular Weight	514.59 g/mol
Synonyms	(R)-2-(Diphenylphosphino)-2'-phenyl-1,1'-binaphthyl; (R)-2-(Diphenylphosphino)-2'-phenyl-[1,1'-binaphthalene]; (R)-2-Diphenylphosphino-2'-phenyl-1,1'-binaphthyl; (R)-Phenyl-PHANEPHOS; (R)-P-Phos; (R)-2-(Diphenylphosphino)-2'-(phenyl)-1,1'-binaphthyl; (R)-2-Diphenylphosphanyl-2'-phenyl-1,1'-binaphthyl; (R)-2-Diphenylphosphino-2'-phenyl-[1,1']binaphthalenyl
EINECS	Contact for details

Quality Control

Our (R)-2-Diphenyphosphino-2'-Phenyl-1,1'-Binaphthyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and elemental analysis, to ensure it meets the high standards required for sensitive asymmetric catalysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation, the container should only be opened in an inert environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.